N-RAS antibody
GTX108598
Overview
- SupplierGeneTex
- Product NameN-RAS antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.41 mg/ml
- ConjugateUnconjugated
- Gene ID4893
- Target nameNRAS
- Target descriptionNRAS proto-oncogene, GTPase
- Target synonymsALPS4; CMNS; GTPase NRas; NCMS; neuroblastoma RAS viral (v-ras) oncogene homolog; neuroblastoma RAS viral oncogene homolog; N-ras; N-ras protein part 4; NRAS1; NS6; transforming protein N-Ras; v-ras neuroblastoma RAS viral oncogene homolog
- HostRabbit
- IsotypeIgG
- Protein IDP01111
- Protein NameGTPase NRas
- Scientific DescriptionThis is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- MLL3 Induced by Luteolin Causes Apoptosis in Tamoxifen-Resistant Breast Cancer Cells through H3K4 Monomethylation and Suppression of the PI3K/AKT/mTOR Pathway. Wu HT et al., 2020, Am J Chin MedRead more
- The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells. Tsuboi M et al., 2017 Oct 27, J Biol ChemRead more
- Differentiation and apoptosis induction by lovastatin and gamma-tocotrienol in HL-60 cells via Ras/ERK/NF-kappaB and Ras/Akt/NF-kappaB signaling dependent down-regulation of glyoxalase 1 and HMG-CoA reductase. Chen CC et al., 2015 Nov, Cell SignalRead more
- Blockade of the Ras/Raf/ERK and Ras/PI3K/Akt Pathways by Monacolin K Reduces the Expression of GLO1 and Induces Apoptosis in U937 Cells. Chen CC et al., 2015 Feb 4, J Agric Food ChemRead more
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