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N-RAS antibody

Name: N-RAS antibody
SKU: GTX108598_G10
Availability: BackOrder

GTX108598

ApplicationsWestern Blot

Product group Antibodies

TargetNRAS

Overview

Supplier
GeneTex
Product Name
N-RAS antibody
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot
Certification
Research Use Only
Clonality
Polyclonal
Concentration
0.41 mg/ml
Conjugate
Unconjugated
Gene ID4893
Target name
NRAS
Target description
NRAS proto-oncogene, GTPase
Target synonyms
ALPS4, CMNS, KRAS, N-ras, NCMS, NRAS1, NS6, GTPase NRas, N-ras protein part 4, neuroblastoma RAS viral (v-ras) oncogene homolog, neuroblastoma RAS viral oncogene homolog, proto-oncogene GTPase, transforming protein N-Ras, v-ras neuroblastoma RAS viral oncogene homolog
Host
Rabbit
Isotype
IgG
Protein IDP01111
Protein Name
GTPase NRas
Scientific Description
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in this gene are a cause of juvenile myelomonocytic leukemia (JMML). [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Wu HT, Liu YE, Hsu KW, et al. MLL3 Induced by Luteolin Causes Apoptosis in Tamoxifen-Resistant Breast Cancer Cells through H3K4 Monomethylation and Suppression of the PI3K/AKT/mTOR Pathway. Am J Chin Med. 2020,48(5):1221-1241. doi: 10.1142/S0192415X20500603
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Tsuboi M, Taniuchi K, Shimizu T, et al. The transcription factor HOXB7 regulates ERK kinase activity and thereby stimulates the motility and invasiveness of pancreatic cancer cells. J Biol Chem. 2017,292(43):17681-17702. doi: 10.1074/jbc.M116.772780
Read this paper
Chen CC, Liu TY, Huang SP, et al. Differentiation and apoptosis induction by lovastatin and γ-tocotrienol in HL-60 cells via Ras/ERK/NF-κB and Ras/Akt/NF-κB signaling dependent down-regulation of glyoxalase 1 and HMG-CoA reductase. Cell Signal. 2015,27(11):2182-90. doi: 10.1016/j.cellsig.2015.07.014
Read this paper
Chen CC, Wu ML, Ho CT, et al. Blockade of the Ras/Raf/ERK and Ras/PI3K/Akt Pathways by Monacolin K Reduces the Expression of GLO1 and Induces Apoptosis in U937 Cells. J Agric Food Chem. 2015,63(4):1186-1195. doi: 10.1021/jf505275s
Read this paper