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NCT-58

ORB1473182
Biorbyt
CAS Number2411429-33-7
Product group Chemicals
Molecular Weight466.57
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Overview

  • Supplier
    Biorbyt
  • Product Name
    NCT-58
  • Delivery Days Customer
    10
  • CAS Number
    2411429-33-7
  • Certification
    Research Use Only
  • Molecular Formula
    C27H34N2O5
  • Molecular Weight
    466.57
  • Scientific Description
    NCT58(NCT 58) is a potent inhibitor of C-terminal HSP90. NCT-58 does not induce the heat shock response (HSR) due to its targeting of the C-terminal region and elicits anti-tumor activity via the simultaneous downregulation of HER family members as well as inhibition of Akt phosphorylation. NCT-58 kills Trastuzumab-resistant breast cancer stem-like cells. NCT-58 induces apoptosis in HER2-positive breast cancer cells.
  • SMILES
    O=C(C1=CC=C2OC(C)(C)C=CC2=C1OC)NC3=CC=C(C(OC)=C3)OCCC4NCCCC4
  • UNSPSC
    12352200

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