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ND-630 [1434635-54-7]

ND-630 [1434635-54-7]

Research Use Only
27071
BPS Bioscience
CAS Number1434635-54-7
Product group Chemicals
Molecular Weight569.63
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Overview

  • Supplier
    BPS Bioscience
  • Product Name
    ND-630
  • Delivery Days Customer
    7
  • CAS Number
    1434635-54-7
  • Certification
    Research Use Only
  • Molecular Formula
    C28H31N3O8S
  • Molecular Weight
    569.63
  • Scientific Description
    ND-630 (NDI 010976) is a highly specific, reversible inhibitor of ACC1 (IC50 = 2 nM) and ACC2 (IC50 = 6 nM). ND-630 interacts within the ACC phosphopeptide acceptor and dimerization site to prevent dimerization of ACC. Because the dimerization site is not conserved among other mammalian carboxylases, ND-630 lacks the ability to inhibit other mechanistically-related enzymes. In rats with diet-induced obesity, ND-630 reduced hepatic steatosis, improved insulin sensitivity, and reduced weight gain, suggesting ACC inhibition may be useful in treating metabolic disorders, including type 2 diabetes mellitus, and fatty liver disease.
  • UNSPSC
    51202000

References

  • Harriman, G., et al., PNAS. 2016, 113 (13): E1796-E1805