Necrostatin-1 [4311-88-0]

AdipoGen Life Sciences

Necrostatin-1

10

4311-88-0

Research Use Only

>98%

C13H13N3OS

259.3

Chemical. CAS: 4311-88-0. Formula: C13H13N3OS. MW: 259.3. Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor. Showed neuroprotection in a murine model of ischemic brain injury in vivo. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor. Used in inflammatory and degenerative disease models to target RIPK1. Suppresses autophagy and apoptosis in murine brain injury models. Cardioprotective and neuroprotective. - Competitive indoleamine 2,3-dioxygenase (IDO) inhibitor [1, 4, 9, 10]. Cell permeable, potent and selective necroptosis (a non-apoptotic form of programmed cell death) inhibitor [2, 5]. Showed neuroprotection in a murine model of ischemic brain injury in vivo [2, 3]. Selective and ATP-competitive receptor-interacting protein kinase 1 (RIPK1) inhibitor [6, 7]. Used in inflammatory and degenerative disease models to target RIPK1 [7, 9, 10]. Suppresses autophagy and apoptosis in murine brain injury models [8, 9]. Cardioprotective and neuroprotective [11-14].

CN1C(=S)NC(CC2=CNC3=CC=CC=C23)C1=O

-20°C,2°C to 8°C

12352200