NEDD4L antibody, Internal

GeneTex

NEDD4L antibody, Internal

9

WB: 0.2-2.5 ug/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot

Research Use Only

Polyclonal

0.5-1 mg/ml

Unconjugated

NEDD4L

NEDD4 like E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase NEDD4-like; HECT-type E3 ubiquitin transferase NED4L; hNEDD4-2; NEDD4.2; NEDD4-2; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; PVNH7; RSP5; ubiquitin-protein ligase Rsp5

Rabbit

IgG

E3 ubiquitin-protein ligase NEDD4-like

This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Human

-20°C or -80°C,2°C to 8°C

12352203