
Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA015699ESR1HU at dilution of 1:100
NEK2 Antibody
CSB-PA015699ESR1HU
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetNEK2
Overview
- SupplierCusabio
- Product NameNEK2 Antibody
- Delivery Days Customer20
- ApplicationsELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID4751
- Target nameNEK2
- Target descriptionNIMA related kinase 2
- Target synonymsHsPK21; NEK2A; NIMA (never in mitosis gene a)-related kinase 2; nimA-like protein kinase 1; nimA-related protein kinase 2; NLK1; PPP1R111; protein phosphatase 1, regulatory subunit 111; RP67; serine/threonine-protein kinase Nek2
- HostRabbit
- IsotypeIgG
- Protein IDP51955
- Protein NameSerine/threonine-protein kinase Nek2
- Scientific DescriptionProtein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and chromatin condensation in meiotic cells. Regulates centrosome separation (essential for the formation of bipolar spindles and high-fidelity chromosome separation) by phosphorylating centrosomal proteins such as CROCC, CEP250 and NINL, resulting in their displacement from the centrosomes. Regulates kinetochore microtubule attachment stability in mitosis via phosphorylation of NDC80. Involved in regulation of mitotic checkpoint protein complex via phosphorylation of CDC20 and MAD2L1. Plays an active role in chromatin condensation during the first meiotic division through phosphorylation of HMGA2. Phosphorylates: PPP1CC; SGOL1; NECAB3 and NPM1. Essential for localization of MAD2L1 to kinetochore and MAPK1 and NPM1 to the centrosome. Isoform 1 phosphorylates and activates NEK11 in G1/S-arrested cells. Isoform 2, which is not present in the nucleolus, does not.
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC41116161