Bio-Connect
Chemical Structure
Chemical Structure
Chemical Structure

Neratinib [698387-09-6]

Research Use Only
CDX-N0326
Chemodex
CAS Number698387-09-6
Product group Chemicals
Estimated Purity>98%
Molecular Weight557
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    Chemodex
  • Product Name
    Neratinib [698387-09-6]
  • Delivery Days Customer
    10
  • CAS Number
    698387-09-6
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Non-hazardous,Warning
  • Molecular Formula
    C30H29ClN6O3
  • Molecular Weight
    557
  • Scientific Description
    Chemical. CAS: 698387-09-6. Formula: C30H29ClN6O3. MW: 557. Neratinib is a cell-permable, irreversible, selective inhibitor of the HER2 kinase (IC50=59nM) and EGFR (IC50=92nM) by preventing phosphorylation of these proteins by their respective kinases. It also potently inhibits several mutants of HER2 and shows 10-fold or greater selectivity over a wide variety of other kinases. As an irreversible inhibitor, neratinib may circumvent acquired resistance developed against reversible inhibitors, including gefitinib. Neratinib displays activity against a variety of cancer cell lines, including A431, 3T3, and MDA-MB-435. Neratinib has been evaluated in clinical trials against cancers characterized by HER2 overexpression or HER2 activating mutations. - Neratinib is a cell-permable, irreversible, selective inhibitor of the HER2 kinase (IC50=59nM) and EGFR (IC50=92nM) by preventing phosphorylation of these proteins by their respective kinases. It also potently inhibits several mutants of HER2 and shows 10-fold or greater selectivity over a wide variety of other kinases. As an irreversible inhibitor, neratinib may circumvent acquired resistance developed against reversible inhibitors, including gefitinib. Neratinib displays activity against a variety of cancer cell lines, including A431, 3T3, and MDA-MB-435. Neratinib has been evaluated in clinical trials against cancers characterized by HER2 overexpression or HER2 activating mutations.
  • SMILES
    CCOC1=C(NC(/C=C/CN(C)C)=O)C=C(C(NC2=CC(Cl)=C(OCC3=NC=CC=C3)C=C2)=C(C#N)C=N4)C4=C1
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352200