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NGEF Polyclonal Antibody

RD218859A
Reddot Biotech
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetNGEF
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    NGEF Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.6 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID25791
  • Target name
    NGEF
  • Target description
    neuronal guanine nucleotide exchange factor
  • Target synonyms
    ARHGEF27; EPHEXIN; ephexin1; ephexin-1; eph-interacting exchange protein
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203