NH-3 [447415-26-1]

TargetMol Chemicals

NH-3 [447415-26-1]

9

447415-26-1

Chemical

Research Use Only

NH-3

C28H27NO6

473.52

NH-3 is a potent orally active thyroid hormone receptor (THR) antagonist which exhibits reversible behavior, demonstrated by an IC 50 of 55 nM. Derived from the selective thyromi-metic GC-1, NH-3 effectively inhibits the binding of thyroid hormones to their respective receptors, resulting in hindered cofactor recruitment.

3 years

CC(C)c1cc(Cc2c(C)cc(OCC(O)=O)cc2C)cc(C#Cc2ccc(cc2)[N+]([O-])=O)c1O

-20°C

12352200