Nigericin

MedChem Express

Nigericin [28380-24-7]

5

28380-24-7

Research Use Only

99.43

C40H68O11

724.96

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K + /H + ionophore , promoting K + /H + exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt / beta-catenin signals. Nigericin induces pyroptosis through caspase 1 /GSDMD in TNBC [1] [2] [3] [4] [5] [6] [7] .

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2°C to 8°C

12352200