Nigericin [28380-24-7]

MedChem Express

Nigericin [28380-24-7]

5

28380-24-7

Research Use Only

99.37

C40H68O11

724.96

Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt/beta-catenin signals. Nigericin induces pyroptosis through caspase 1/GSDMD in TNBC[1][2][3][4][5][6][7].

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2°C to 8°C

12352200