Nigericin [28380-24-7]

TargetMol Chemicals

Nigericin [28380-24-7]

999

28380-24-7

Chemical

Research Use Only

Nigericin

C40H68O11

724.96

Nigericin, an antibiotic derived from Streptomyces hygroscopicus, acts as a K+/H+ ionophore, promoting K+/H+ exchange across mitochondrial membranes. It can activate NLRP3 and cause the release of IL-1beta in a NALP3-dependent manner. Nigericin induces eryptosis, partly due to oxidative stress and ROS formation, and also causes apoptosis.

3 years

[H][C@@]1(C[C@H](C)[C@@]([H])(O1)[C@]1(C)CC[C@@]([H])(O1)[C@]1(C)C[C@@H](C)[C@]2(O1)O[C@]([H])(C[C@@]1([H])CC[C@H](C)[C@@]([H])(O1)[C@@H](C)C(O)=O)C[C@@H](OC)[C@H]2C)[C@@]1([H])O[C@@](O)(CO)[C@H](C)C[C@@H]1C

-20°C

12352200