Niraparib (hydrochloride)

MedChem Express

Niraparib (hydrochloride) [1038915-64-8]

9

1038915-64-8

Research Use Only

99.41

C19H21ClN4O

356.85

Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. Niraparib hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity[1][2][3].

NC(C1=CC=CC2=CN(C3=CC=C([C@H]4CNCCC4)C=C3)N=C21)=O.Cl

2°C to 8°C

12352200