Niraparib (MK-4827)
M2215
CAS Number1038915-60-4
Product group Chemicals
Estimated Purity0.996
Molecular Weight320.39
Overview
- SupplierAbMole BioScience
- Product NameNiraparib (MK-4827)
- Delivery Days Customer9
- CAS Number1038915-60-4
- Category SupplierChemical
- CertificationResearch Use Only
- Estimated Purity0.996
- Molecular FormulaC19H20N4O
- Molecular Weight320.39
- Scientific DescriptionMK-4827 (Niraparib) is a selective PARP1/2 inhibitor with an IC50 value of 3.8 nM/2.1 nM that increases the formation of PARP-DNA complexes through inhibition of PARPase activity, leading to DNA damage, apoptosis, PARP-1-dependent cell death (parthanatos) and cell death. Strong effector activity when acting on cancer cells harboring mutant BRCA-1 and BRCA-2. It is more than 330-fold more selective than PARP3, V-PARP and Tank1.
- SMILESNC(=O)C1=CC=CC2=C[N](N=C12)C3=CC=C(C=C3)C4CCCNC4
- UNSPSC12352200