Bio-Connect

Niraparib (MK-4827)

M2215
AbMole BioScience
CAS Number1038915-60-4
Product group Chemicals
Estimated Purity0.996
Molecular Weight320.39
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Overview

  • Supplier
    AbMole BioScience
  • Product Name
    Niraparib (MK-4827)
  • Delivery Days Customer
    9
  • CAS Number
    1038915-60-4
  • Category Supplier
    Chemical
  • Certification
    Research Use Only
  • Estimated Purity
    0.996
  • Molecular Formula
    C19H20N4O
  • Molecular Weight
    320.39
  • Scientific Description
    MK-4827 (Niraparib) is a selective PARP1/2 inhibitor with an IC50 value of 3.8 nM/2.1 nM that increases the formation of PARP-DNA complexes through inhibition of PARPase activity, leading to DNA damage, apoptosis, PARP-1-dependent cell death (parthanatos) and cell death. Strong effector activity when acting on cancer cells harboring mutant BRCA-1 and BRCA-2. It is more than 330-fold more selective than PARP3, V-PARP and Tank1.
  • SMILES
    NC(=O)C1=CC=CC2=C[N](N=C12)C3=CC=C(C=C3)C4CCCNC4
  • UNSPSC
    12352200