NKX3.1 (Metastatic Prostate Adenocarcinoma Marker)(NKX3.1/3348), 0.2mg/mL [26628-22-8]

Biotium

NKX3.1 (Metastatic Prostate Adenocarcinoma Marker)(NKX3.1/3348), 0.2mg/mL [26628-22-8]

9

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

26628-22-8

Research Use Only

Monoclonal

NKX3.1/3348

0.2 mg/ml

NKX3-1

NK3 homeobox 1

BAPX2, NKX3, NKX3.1, NKX3A, homeobox protein Nkx-3.1, NK homeobox, family 3, A, NK3 transcription factor homolog A, NK3 transcription factor related, locus 1, homeobox protein NK-3 homolog A

Mouse

IgG2b

Homeobox protein Nkx-3.1

NKX3. 1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21. 2, which frequently undergoes a loss of heterozygosity. NKX3. 1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3. 1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3. 1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Human

2°C to 8°C,RT

41116161