NLRP2 Antibody

Cusabio

NLRP2 Antibody

20

Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

NLRP2

NLR family pyrin domain containing 2

CLR19.9, NALP2, NBS1, OZEMA18, PAN1, PYPAF2, NACHT, LRR and PYD domains-containing protein 2, NACHT, leucine rich repeat and PYD containing 2, PYRIN domain and NACHT domain-containing protein 1, PYRIN-containing APAF1-like protein 2, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 2, nucleotide-binding site protein 1

Rabbit

IgG

NACHT, LRR and PYD domains-containing protein 2

Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF. When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B. May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.

Human

-20°C or -80°C

41116161