NMI Antibody / N-myc and STAT interactor / N-Myc Interactor

Biorbyt

NMI Antibody / N-myc and STAT interactor / N-Myc Interactor

10

Optimal dilution of the N-Myc Interactor antibody should be determined by the researcher.

Flow Cytometry

Flow cytometry: 1-2ug/million cells FACS

Research Use Only

Monoclonal

PCRP-NMI-1C1

Unconjugated

NMI

N-myc and STAT interactor

N-myc-interactor

Mouse

IgG2b

N-myc-interactor

Nmi (for N-Myc interactor) is an interferon inducible protein that associates with multiple transcription factors, including c-Myc, n-Myc, Max, and c-Fos, which contain bHLH-ZIP, bHLH, or Zip domains. Nmi is ubiquitously expressed at low levels throughout various fetal and adult tissues and at higher levels in myeloid leukemias and cell lines overexpressing c-Myc. In addition to binding Myc proteins, Nmi also associates with the Stat family of transcription factors, where it enhances Stat-dependent transcription. Although Nmi lacks an intrinsic DNA binding or activation domain, Nmi enhances the transcriptional activity of the Stat proteins, in response to cytokine stimulation, by recruiting the Stat1 and Stat5 transcriptional coactivators, CREB-binding protein (CBP) and p300. In vitro studies indicate that Nmi, expressed in conjunction with CBP, enhances the transcriptional responsiveness of Stat5 to IL-2 stimulation five-fold over CBP alone by increasing the affinity of Stat proteins for CBP/p300.

Human

-20°C,2°C to 8°C

12352203