Nolatrexed dihydrochloride [152946-68-4]
HY-108474
CAS Number152946-68-4
Product group Chemicals
Estimated Purity98.38%
Molecular Weight357.26
Overview
- SupplierMedChem Express
- Product NameNolatrexed dihydrochloride [152946-68-4]
- Delivery Days Customer10
- CAS Number152946-68-4
- Estimated Purity98.38%
- Molecular FormulaC14H14Cl2N4OS
- Molecular Weight357.26
- Scientific DescriptionNolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity.
- SMILES[H]Cl.O=C1N=C(N)NC2=C1C(SC3=CC=NC=C3)=C(C)C=C2.[H]Cl
- Storage Instruction-20°C,-80°C
- UNSPSC12352200