Nolatrexed dihydrochloride
HY-108474
Overview
- SupplierMedChem Express
- Product NameNolatrexed dihydrochloride [152946-68-4]
- Delivery Days Customer10
- CAS Number152946-68-4
- CertificationResearch Use Only
- Estimated Purity98.38
- Molecular FormulaC14H14Cl2N4OS
- Molecular Weight357.26
- Scientific DescriptionNolatrexed dihydrochloride (AG 337) is an orally active and non-competitive lipophilic inhibitor of thymidylate synthase with a Ki of 11 nM for human thymidylate synthase. Nolatrexed dihydrochloride interacts at the folate cofactor binding site of the enzyme. Nolatrexed dihydrochloride increases sulfotransferases. Nolatrexed dihydrochloride induces cell cycle arrest in S phase of cancer cells. Nolatrexed dihydrochloride exhibits anticancer activity against cervical cancer.
- SMILES[H]Cl.O=C1N=C(N)NC2=C1C(SC3=CC=NC=C3)=C(C)C=C2.[H]Cl
- Storage Instruction-20°C
- UNSPSC12352200
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Product group Chemicals
CAS Number152946-68-4
Estimated Purity97.02%
Molecular Weight357.26
- SizePrice
Product group Chemicals
Nolatrexed dihydrochlorideORB1701525
CAS Number152946-68-4
Estimated Purity100%
Molecular Weight357.26
- SizePrice
Product group Chemicals
CAS Number152946-68-4
- SizePrice
Product group Chemicals
CAS Number152946-68-4
Molecular Weight357.26 g/mol
- SizePrice