Nolatrexed dihydrochloride [152946-68-4]
T2627
CAS Number152946-68-4
Product group Chemicals
Estimated Purity97.02%
Molecular Weight357.26
Overview
- SupplierTargetMol Chemicals
- Product NameNolatrexed dihydrochloride
- Delivery Days Customer10
- CAS Number152946-68-4
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NameNolatrexed dihydrochloride
- Estimated Purity97.02%
- Molecular FormulaC14H14Cl2N4OS
- Molecular Weight357.26
- Scientific DescriptionNolatrexed dihydrochloride (Thymitaq) is the dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity.
- Shelf life instruction3 years
- SMILESCl.Cl.Cc1ccc2[nH]c(N)nc(=O)c2c1Sc1ccncc1
- Storage Instruction-20°C
- UNSPSC12352200
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