IHC-P analysis of human kidney tissue using Notch 2 antibody at a dilution of 1:500. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain.
IHC-P analysis of human kidney tissue using Notch 2 antibody at a dilution of 1:500. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain.
NOTCH2 antibody
GTX28927
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
ReactivityHuman
TargetNOTCH2
Overview
- SupplierGeneTex
- Product NameNOTCH2 antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:400-1:2000. IHC-P: 1:200-1:800. ELISA: 1:30000-1:90000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration75 mg/ml
- ConjugateUnconjugated
- Gene ID4853
- Target nameNOTCH2
- Target descriptionnotch receptor 2
- Target synonymsAGS2; HJCYS; hN2; neurogenic locus notch homolog protein 2; notch 2; Notch homolog 2
- HostRabbit
- IsotypeIgG
- Protein IDQ04721
- Protein NameNeurogenic locus notch homolog protein 2
- Scientific DescriptionSynthesized in the endoplasmic reticulum as an inactive form, which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs.
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203