NSC 617145

MedChem Express

NSC 617145 [203115-63-3]

10

203115-63-3

Research Use Only

99.18

C13H10Cl4N2O4

400.04

NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC 50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases [1] .

O=C(C(Cl)=C(Cl)C1=O)N1CC(C)(C)CN2C(C(Cl)=C(Cl)C2=O)=O

-20°C,2°C to 8°C

12352200