Obatoclax [803712-79-0]

BPS Bioscience

Obatoclax

7

803712-79-0

Research Use Only

≥99%

C20H19N3O CH4SO3

413.5 Da

Obatoclax, also known as GX15-070, is a novel Bcl-2 homology domain-3 (BH3) mimetic. It occupies a hydrophobic cleft within the BH3 binding groove of Bcl-2, antagonizing Bcl-2 and thus inducing apoptosis. Obatoclax inhibited primary acute myeloid leukemia (AML) progenitor cell proliferation with an average IC50 of 0.18 +/- 0.07 microM, and it potently induced apoptosis in primary AML cells with an average IC50 of 3.6 +/- 1.2 microM. Obatoclax overcomes Bcl-2-, Bcl-xL-, Bcl-w-, and Mcl-1-mediated resistance to BAX or BAK and to the proteasome inhibitor bortezomib.

-20°C

51202000