Orai1 antibody

GeneTex

Orai1 antibody

9

WB: 0.5 - 2 microg/mL. IHC-P: 2.5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

ORAI1

ORAI calcium release-activated calcium modulator 1

CRACM1, IMD9, ORAT1, TAM2, TMEM142A, calcium release-activated calcium channel protein 1, calcium release-activated calcium modulator 1, protein orai-1, transmembrane protein 142A

Rabbit

IgG

Calcium release-activated calcium channel protein 1

Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI1 is a recently identified four-transmembrane spanning protein that is an essential component of CRAC. A missense mutation in this protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated T-cell Ca++ entry. It has been suggested that ORAI1 functions as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. ORAI1 often migrates at a higher than expected molecular weight in SDS-PAGE. This antibody is predicted to have no cross-reactivity to ORAI2 or ORAI3.

-20°C or -80°C,2°C to 8°C

12352203