ORC1 antibody [7A7]

GeneTex

ORC1 antibody [7A7]

9

Human ORC1

Recommended Starting Dilutions:For WB: Use at 1:1000Optimal dilutions should be determined experimentally by the researcher.

ImmunoPrecipitation, Western Blot

Research Use Only

Monoclonal

7A7

1 mg/ml

Unconjugated

ORC1

origin recognition complex subunit 1

HSORC1; ORC1L; origin recognition complex subunit 1; origin recognition complex, subunit 1 homolog; PARC1; replication control protein 1

Rat

IgG1

Origin recognition complex subunit 1

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Human

-20°C or -80°C,2°C to 8°C

12352203