Orthoformimycin [1450896-99-7]

Name: Orthoformimycin [1450896-99-7]
SKU: AG-CN2-0314_A27
Availability: BackOrder

AG-CN2-0314

CAS Number1450896-99-7

Product group Chemicals

Estimated Purity>80%

Molecular Weight539.6

Overview

Supplier
AdipoGen Life Sciences
Product Name
Orthoformimycin
Delivery Days Customer
10
CAS Number
1450896-99-7
Certification
Research Use Only
Estimated Purity
>80%
Molecular Formula
C25H37N3O10
Molecular Weight
539.6
Scientific Description
Chemical. CAS: 1450896-99-7 [A], 1450897-02-5 [B]. Formula: C25H37N3O10. MW: 539.6. Isolated from Streptomyces sp. Cinnamoyl aminoglycoside antibiotic. Protein synthesis inhibitor in vitro. Selective inhibitor of bacterial translation elongation, through binding to the 50S subunit. Inhibits EF-G-dependent mRNA translocation but not translocation of the aminoacyl-tRNA. Moderate antibacterial compound, in both Gram-positive and Gram-negative bacteria. - Cinnamoyl aminoglycoside antibiotic. Protein synthesis inhibitor in vitro. Selective inhibitor of bacterial translation elongation, through binding to the 50S subunit. Inhibits EF-G-dependent mRNA translocation but not translocation of the aminoacyl-tRNA. Moderate antibacterial compound in both Gram-positive and Gram-negative bacteria.
SMILES
O=C(/C(C)=C/C1=CC=C(C=C1)N(C)C)NC2C(C(C3OC(OC(C(CO)O)C(O)=O)OC3C2N(C)C)O)O
Storage Instruction
-20°C,2°C to 8°C
UNSPSC
12352200

Orthoformimycin, a selective inhibitor of bacterial translation elongation from Streptomyces containing an unusual orthoformate: S.I. Maffioli, et al.; ACS Chem. Biol. 8, 1939 (2013)
Discovering new bioactive molecules from microbial sources: P. Monciardini, et al.; Microb. Biotechnol. 7, 209 (2014) (Review)