P Glycoprotein antibody
GTX108370
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman
TargetABCB1
Overview
- SupplierGeneTex
- Product NameP Glycoprotein antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.77 mg/ml
- ConjugateUnconjugated
- Gene ID5243
- Target nameABCB1
- Target descriptionATP binding cassette subfamily B member 1
- Target synonymsABC20, CD243, CLCS, ENPAT, GP170, MDR1, P-GP, PGY1, p-170, ATP-dependent translocase ABCB1, ATP-binding cassette, sub-family B (MDR/TAP), member 1, P-glycoprotein 1, colchicin sensitivity, doxorubicin resistance, multidrug resistance protein 1, phospholipid transporter ABCB1
- HostRabbit
- IsotypeIgG
- Protein IDP08183
- Protein NameATP-dependent translocase ABCB1
- Scientific DescriptionThe membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Hsia Y, Sivasubramanian M, Chu CH, et al. A Dual Concentration-Tailored Cytokine-Chemo Nanosystem to Alleviate Multidrug Resistance and Redirect Balance of Cancer Proliferation and Apoptosis. Int J Nanomedicine. 2023,18:4253-4274. doi: 10.2147/IJN.S412932Read this paper
- Jadhao M, Tsai EM, Yang HC, et al. The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS. Antioxidants (Basel). 2021,10(6). doi: 10.3390/antiox10060949Read this paper
- Lanzillotta C, Zuliani I, Tramutola A, et al. Chronic PERK induction promotes Alzheimer-like neuropathology in Down syndrome: Insights for therapeutic intervention. Prog Neurobiol. 2021,196:101892. doi: 10.1016/j.pneurobio.2020.101892Read this paper
- Chen Q, Liu X, Luo Z, et al. Chloride channel-3 mediates multidrug resistance of cancer by upregulating P-glycoprotein expression. J Cell Physiol. 2019,234(5):6611-6623. doi: 10.1002/jcp.27402Read this paper
- Yeh YH, Hsiao HF, Yeh YC, et al. Inflammatory interferon activates HIF-1α-mediated epithelial-to-mesenchymal transition via PI3K/AKT/mTOR pathway. J Exp Clin Cancer Res. 2018,37(1):70. doi: 10.1186/s13046-018-0730-6Read this paper
- Chang HP, Lu CC, Chiang JH, et al. Pterostilbene modulates the suppression of multidrug resistance protein 1 and triggers autophagic and apoptotic mechanisms in cisplatin-resistant human oral cancer CAR cells via AKT signaling. Int J Oncol. 2018,52(5):1504-1514. doi: 10.3892/ijo.2018.4298Read this paper
- Maruhashi R, Akizuki R, Sato T, et al. Elevation of sensitivity to anticancer agents of human lung adenocarcinoma A549 cells by knockdown of claudin-2 expression in monolayer and spheroid culture models. Biochim Biophys Acta Mol Cell Res. 2018,1865(3):470-479. doi: 10.1016/j.bbamcr.2017.12.005Read this paper
- Lin GL, Ting HJ, Tseng TC, et al. Modulation of the mRNA-binding protein HuR as a novel reversal mechanism of epirubicin-triggered multidrug resistance in colorectal cancer cells. PLoS One. 2017,12(10):e0185625. doi: 10.1371/journal.pone.0185625Read this paper
- Yeh WL, Tsai CF, Chen DR. Peri-foci adipose-derived stem cells promote chemoresistance in breast cancer. Stem Cell Res Ther. 2017,8(1):177. doi: 10.1186/s13287-017-0630-2Read this paper
- Lo YW, Lin ST, Chang SJ, et al. Mitochondrial proteomics with siRNA knockdown to reveal ACAT1 and MDH2 in the development of doxorubicin-resistant uterine cancer. J Cell Mol Med. 2015,19(4):744-59. doi: 10.1111/jcmm.12388Read this paper
Datasheet
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