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Ubiquitinated-p53 Western Blot: From left to right: Control His6-p53 (50ng), ubiquitinated-p53 (50ng and 100ng) and ubiquitinated-p53 digested with USP7 (50ng).
Ubiquitinated-p53 Western Blot: From left to right: Control His6-p53 (50ng), ubiquitinated-p53 (50ng and 100ng) and ubiquitinated-p53 digested with USP7 (50ng).
Ubiquitinated-p53 Western Blot: From left to right: Control His6-p53 (50ng), ubiquitinated-p53 (50ng and 100ng) and ubiquitinated-p53 digested with USP7 (50ng).

p53 (polyubiquitinated) (human) (rec.) (His)

SBB-US0012
South Bay Bio
Protein IDP04637
Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    South Bay Bio
  • Product Name
    p53 (polyubiquitinated) (human) (rec.) (His)
  • Delivery Days Customer
    10
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Protein IDP04637
  • Protein Name
    Cellular tumor antigen p53
  • Scientific Description
    p53 acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. E3 ligase MDM2 mediated ubiquitin conjugation of p53 and subsequent p53 down-regulation via proteasomal degradation interrupts this crucial role, contributing to tumorogenesis (and cancer). - Protein. Human p53 (aa 2-393)fused to a N-terminal His-tag, ubiquitinated by MDM2, and subsequently purified from conjugation-reaction proteins/enriched post-conjugation. Source: E. coli. Formulation: Liquid. In 50mM HEPES pH 7.5, 500 mM sodium chloride, 10% glycerol, 2mM TCEP. Purity: >95% (SDS-PAGE). p53 acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. E3 ligase MDM2 mediated ubiquitin conjugation of p53 and subsequent p53 down-regulation via proteasomal degradation interrupts this crucial role, contributing to tumorogenesis (and cancer).
  • Storage Instruction
    -80°C
  • UNSPSC
    12352202

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Immunohistochemical staining of formalin fixed and paraffin embedded human lung cancer tissue section using anti-p53 rabbit monoclonal antibody (Clone RM 387) at a 1:100 dilution.
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ApplicationsWestern Blot, ImmunoHistoChemistry
ReactivityHuman
TargetTP53
  • SizePrice