P62/SQSTM1 Polyclonal Antibody

Reddot Biotech

P62/SQSTM1 Polyclonal Antibody

5

Western Blot

Research Use Only

Polyclonal

0.58 mg/ml

Unconjugated

SQSTM1

sequestosome 1

A170, DMRV, EBIAP, FTDALS3, NADGP, OSIL, PDB3, ZIP3, p60, p62, p62B, sequestosome-1, EBI3-associated protein of 60 kDa, EBI3-associated protein p60, autophagy receptor p62, oxidative stress induced like, phosphotyrosine independent ligand for the Lck SH2 domain p62, phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa, ubiquitin-binding protein p62

Rabbit

IgG

Sequestosome-1

Sequestosome 1 (SQSTM1/p62) is a multifunctional adaptor protein implicated in selective autophagy,cell signaling pathways,and tumorigenesis. p62 has been implicated in shuttling ubiquitinated and sometimes aggregated proteins for autophagic degradation. As a autophagy-specific substrate,p62 is degraded during the autophagic process,which makes intracellular level of p62 as a marker for autophagy flux. p62 is at the cross-roads of several signaling pathways including Ras/ Raf/ MAPK and NFkappaB and plays important role in cancer. p62 is a component of inclusion bodies/ protein aggregates found in human diseases,including Huntingtons disease,Alzheimers disease,Parkinsons disease in the brain,and nephropathic cystinosis in kidney (22074114,22860231,22714671). The molecular weight of p62 is predicted as 48/ 38 kDa,while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues. - This is a P62/SQSTM1 Polyclonal Antibody from Reddot Biotech. This product is for Research Use Only.

Human, Mouse, Rat

-20°C

41116161