Bio-Connect

SQSTM1 / P62 antibody [N3C1], Internal

GTX100685
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
Product group Antibodies
ReactivityBovine, Human, Insect, Mouse, Rat, Zebra Fish
TargetSQSTM1
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Overview

  • Supplier
    GeneTex
  • Product Name
    SQSTM1 / P62 antibody [N3C1], Internal
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. FACS: 1:50-1:200. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin, Other Application
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.39 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID8878
  • Target name
    SQSTM1
  • Target description
    sequestosome 1
  • Target synonyms
    A170; autophagy receptor p62; DMRV; EBI3-associated protein of 60 kDa; EBI3-associated protein p60; EBIAP; FTDALS3; NADGP; OSIL; oxidative stress induced like; p60; p62; p62B; PDB3; phosphotyrosine independent ligand for the Lck SH2 domain p62; phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa; sequestosome-1; ubiquitin-binding protein p62; ZIP3
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ13501
  • Protein Name
    Sequestosome-1
  • Scientific Description
    This gene encodes a multifunctional protein that binds ubiquitin and regulates activation of the nuclear factor kappa-B (NF-kB) signaling pathway. The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. Mutations in this gene result in sporadic and familial Paget disease of bone. [provided by RefSeq]
  • Reactivity
    Bovine, Human, Insect, Mouse, Rat, Zebra Fish
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Fucose ameliorates the proinflammatory property of Fusobacterium nucleatum in colitis via altering its metabolism.
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  • Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma.
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  • Tumor suppressive functions of hsa-miR-34a on cell cycle, migration and protective autophagy in bladder cancer.
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  • Combination of chloroquine diphosphate and salidroside induces human liver cell apoptosis via regulation of mitochondrial dysfunction and autophagy.
    Read more
  • The combination of high glucose and LPS induces autophagy in bovine kidney epithelial cells via the Notch3/mTOR signaling pathway.
    Read more
  • Modulation of autophagy, apoptosis and oxidative stress: a clue for repurposing metformin in photoaging.
    Read more
  • Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration. Guo Y et al., 2022 Jul 15, iScience
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  • Notch3-Mediated mTOR Signaling Pathway Is Involved in High Glucose-Induced Autophagy in Bovine Kidney Epithelial Cells. Cui Y et al., 2022 May 13, Molecules
    Read more
  • UXT attenuates the CGAS-STING1 signaling by targeting STING1 for autophagic degradation.
    Read more
  • TFEB- and TFE3-dependent autophagy activation supports cancer proliferation in the absence of centrosomes. Kao CH et al., 2022 Dec, Autophagy
    Read more