p73 antibody [5B429]

GeneTex

p73 antibody [5B429] - Overexpression Validated

9

WB: 2 microg/ml. ICC/IF: 1:20 - 1:1000. IHC-P: 5 - 15 microg/ml. IHC-Fr: 5 - 15 microg/ml. FACS: 1 microg/ml. IP: 1:20 - 1:1000. ChIP assay: 1:20 - 1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Mass Spectrometry, Western Blot, ChIP Chromatin ImmunoPrecipitation, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

5B429

1 mg/ml

Unconjugated

TP73

tumor protein p73

CILD47, P73, tumor protein p73, p53-like transcription factor, p53-related protein

Mouse

IgG1

Tumor protein p73

This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each others promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq]

-20°C or -80°C,2°C to 8°C

12352203