Pacritinib [937272-79-2]

MedChem Express

Pacritinib [937272-79-2]

4

937272-79-2

Research Use Only

99.93

C28H32N4O3

472.58

Pacritinib (SB1518) is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM). Pacritinib also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM).

C1(COC/C=C/COCC2=C(OCCN3CCCC3)C=CC4=C2)=CC=CC(C5=N/C(NC=C5)=N\4)=C1

-20°C, 3 years; 4°C, 2 years (Powder)

12352200