The data was published in the journal Cancers (Basel) in 2020. PMID: 32218208
![FACS analysis of HEK293T cells transfected with either PAICS plasmid(Red) or empty vector control plasmid(Blue) using GTX83950 PAICS antibody [2C9].](https://www.genetex.com/upload/website/prouct_img/normal/GTX83950/GTX83950_254_FACS_w_23061420_722.webp "FACS analysis of HEK293T cells transfected with either PAICS plasmid(Red) or empty vector control plasmid(Blue) using GTX83950 PAICS antibody [2C9].")
![WB analysis of various samples using GTX83950 PAICS antibody [2C9]. Loading : 10 ug per lane Dilution : 1:200](https://www.genetex.com/upload/website/prouct_img/normal/GTX83950/GTX83950_3479_WB_w_23061420_586.webp "WB analysis of various samples using GTX83950 PAICS antibody [2C9]. Loading : 10 ug per lane Dilution : 1:200")
The data was published in the journal Cancers (Basel) in 2020. PMID: 32218208
PAICS antibody [2C9]
GTX83950
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetPAICS
Overview
- SupplierGeneTex
- Product NamePAICS antibody [2C9] - Overexpression Validated
- Delivery Days Customer9
- Application Supplier NoteWB: 1:2000. ICC/IF: 1:100. FACS: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID2C9
- Concentration0.63 mg/ml
- ConjugateUnconjugated
- Gene ID10606
- Target namePAICS
- Target descriptionphosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
- Target synonymsADE2; ADE2H1; AIR carboxylase; AIRC; multifunctional protein ADE2; multifunctional protein ADE2H1; PAIS; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase; phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase; SAICAR synthetase
- HostMouse
- IsotypeIgG1
- Protein IDP22234
- Protein NameMultifunctional protein ADE2
- Scientific DescriptionThis gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
- ReactivityHuman, Mouse
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1.Read more
- MicroRNA-21 guide and passenger strand regulation of adenylosuccinate lyase-mediated purine metabolism promotes transition to an EGFR-TKI-tolerant persister state.Read more
- PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression. Agarwal S et al., 2020 Jul, Transl OncolRead more
- PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer. Agarwal S et al., 2020 Mar 25, Cancers (Basel)Read more
- Lentivirus-mediated CDglyTK gene-modified free flaps by intra-artery perfusion show targeted therapeutic efficacy in rat model of breast cancer. Zhang J et al., 2019 Sep 14, BMC CancerRead more
- A Role for De Novo Purine Metabolic Enzyme PAICS in Bladder Cancer Progression. Chakravarthi BVSK et al., 2018 Sep, NeoplasiaRead more
- Expression and Role of PAICS, a De Novo Purine Biosynthetic Gene in Prostate Cancer. Chakravarthi BV et al., 2017 Jan, ProstateRead more