PAICS antibody [2C9]

GTX83950

ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

ReactivityHuman, Mouse

TargetPAICS

Overview

Supplier
GeneTex
Product Name
PAICS antibody [2C9]
Delivery Days Customer
9
Application Supplier Note
WB: 1:2000. ICC/IF: 1:100. FACS: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
2C9
Concentration
0.63 mg/ml
Conjugate
Unconjugated
Gene ID10606
Target name
PAICS
Target description
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
Target synonyms
ADE2, ADE2H1, AIRC, PAICSD, PAIS, bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase, AIR carboxylase, SAICAR synthetase, multifunctional protein ADE2, multifunctional protein ADE2H1, phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase
Host
Mouse
Isotype
IgG1
Protein IDP22234
Protein Name
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase
Scientific Description
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Reactivity
Human, Mouse
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

References

Aftab F, Rodriguez-Fuguet A, Silva L, et al. An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1. Br J Cancer. 2023,128(9):1647-1664. doi: 10.1038/s41416-023-02196-z
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Zhang WC, Skiados N, Aftab F, et al. MicroRNA-21 guide and passenger strand regulation of adenylosuccinate lyase-mediated purine metabolism promotes transition to an EGFR-TKI-tolerant persister state. Cancer Gene Ther. 2022,29(12):1878-1894. doi: 10.1038/s41417-022-00504-y
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Agarwal S, Chakravarthi BVSK, Kim HG, et al. PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression. Transl Oncol. 2020,13(7):100776. doi: 10.1016/j.tranon.2020.100776
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Agarwal S, Chakravarthi BVSK, Behring M, et al. PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer. Cancers (Basel). 2020,12(4). doi: 10.3390/cancers12040772
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Zhang J, Liu Y, Zang M, et al. Lentivirus-mediated CDglyTK gene-modified free flaps by intra-artery perfusion show targeted therapeutic efficacy in rat model of breast cancer. BMC Cancer. 2019,19(1):921. doi: 10.1186/s12885-019-6111-5
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Chakravarthi BVSK, Rodriguez Pena MDC, Agarwal S, et al. A Role for De Novo Purine Metabolic Enzyme PAICS in Bladder Cancer Progression. Neoplasia. 2018,20(9):894-904. doi: 10.1016/j.neo.2018.07.006
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Chakravarthi BV, Goswami MT, Pathi SS, et al. Expression and Role of PAICS, a De Novo Purine Biosynthetic Gene in Prostate Cancer. Prostate. 2017,77(1):10-21. doi: 10.1002/pros.23243
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PAICS antibody [2C9]

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