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The data was published in the journal Cancers (Basel) in 2020. PMID: 32218208
The data was published in the journal Cancers (Basel) in 2020. PMID: 32218208
The data was published in the journal Cancers (Basel) in 2020. PMID: 32218208

PAICS antibody [2C9]

GTX83950
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetPAICS
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Overview

  • Supplier
    GeneTex
  • Product Name
    PAICS antibody [2C9] - Overexpression Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:2000. ICC/IF: 1:100. FACS: 1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    2C9
  • Concentration
    0.63 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID10606
  • Target name
    PAICS
  • Target description
    phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  • Target synonyms
    ADE2; ADE2H1; AIR carboxylase; AIRC; multifunctional protein ADE2; multifunctional protein ADE2H1; PAIS; phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase; phosphoribosylaminoimidazole carboxylase; phosphoribosylaminoimidazolesuccinocarboxamide synthase; SAICAR synthetase
  • Host
    Mouse
  • Isotype
    IgG1
  • Protein IDP22234
  • Protein Name
    Multifunctional protein ADE2
  • Scientific Description
    This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1.
    Read more
  • MicroRNA-21 guide and passenger strand regulation of adenylosuccinate lyase-mediated purine metabolism promotes transition to an EGFR-TKI-tolerant persister state.
    Read more
  • PAICS, a De Novo Purine Biosynthetic Enzyme, Is Overexpressed in Pancreatic Cancer and Is Involved in Its Progression. Agarwal S et al., 2020 Jul, Transl Oncol
    Read more
  • PAICS, a Purine Nucleotide Metabolic Enzyme, is Involved in Tumor Growth and the Metastasis of Colorectal Cancer. Agarwal S et al., 2020 Mar 25, Cancers (Basel)
    Read more
  • Lentivirus-mediated CDglyTK gene-modified free flaps by intra-artery perfusion show targeted therapeutic efficacy in rat model of breast cancer. Zhang J et al., 2019 Sep 14, BMC Cancer
    Read more
  • A Role for De Novo Purine Metabolic Enzyme PAICS in Bladder Cancer Progression. Chakravarthi BVSK et al., 2018 Sep, Neoplasia
    Read more
  • Expression and Role of PAICS, a De Novo Purine Biosynthetic Gene in Prostate Cancer. Chakravarthi BV et al., 2017 Jan, Prostate
    Read more

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