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ProductsBack/PAK (phospho Ser141) antibody
WB analysis of whole cell extracts (30 microg lysate) of SH-SY5Y (Lane 1) treated with 100 uM Pervanadate for 1 hour (Lane 2), HeLa (Lane 3) treated with 100 uM Pervanadate for 1 hour (Lane 4), K562 (Lane 5) treated with 100 uM Pervanadate for 1 hour (Lane 6) using GTX25247 PAK2 (phospho Ser141) antibody. Dilution : 1:500
WB analysis of whole cell extracts (30 microg lysate) of SH-SY5Y (Lane 1) treated with 100 uM Pervanadate for 1 hour (Lane 2), HeLa (Lane 3) treated with 100 uM Pervanadate for 1 hour (Lane 4), K562 (Lane 5) treated with 100 uM Pervanadate for 1 hour (Lane 6) using GTX25247 PAK2 (phospho Ser141) antibody. Dilution : 1:500
WB analysis of whole cell extracts (30 microg lysate) of SH-SY5Y (Lane 1) treated with 100 uM Pervanadate for 1 hour (Lane 2), HeLa (Lane 3) treated with 100 uM Pervanadate for 1 hour (Lane 4), K562 (Lane 5) treated with 100 uM Pervanadate for 1 hour (Lane 6) using GTX25247 PAK2 (phospho Ser141) antibody. Dilution : 1:500

PAK (phospho Ser141) antibody

GTX25247
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
DownloadDatasheet
Product group Antibodies
ReactivityBovine, Human, Mouse, Rat
TargetPAK1
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Overview

  • Supplier
    GeneTex
  • Product Name
    PAK (phospho Ser141) antibody - Orthogonal Validated
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID5058
  • Target name
    PAK1
  • Target description
    p21 (RAC1) activated kinase 1
  • Target synonyms
    alpha-PAK; IDDMSSD; p21 protein (Cdc42/Rac)-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p65-PAK; PAKalpha; serine/threonine-protein kinase PAK 1; STE20 homolog, yeast
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDO75914
  • Protein Name
    Serine/threonine-protein kinase PAK 3
  • Scientific Description
    P21-activated kinase (PAK) is actually a family of serine/threonine protein kinases, members of which are activated by small molecular weight GTPases. The three most common isoforms are PAK 1, PAK 2, and PAK 3 (also known as alpha PAK, gamma PAK, and beta PAK, respectively). These kinases contain numerous regulatory elements that trigger diverse signaling processes such as those initiated by activated GTPases, interaction with Src homology 3 (SH3) domains, and caspase mediated proteolytic cleavage. Autophosphorylation of serine 141 (serine 144 for PAK 1 and serine 139 PAK 3), catalyzed by Cdc42, is required for activation of PAK.
  • Reactivity
    Bovine, Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • PAK1 confers chemoresistance and poor outcome in non-small cell lung cancer via beta-catenin-mediated stemness. Chen MJ et al., 2016 Oct 7, Sci Rep
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