Calibration curve for PAPP-A sandwich immunoassay. Capture: PAPP A antibody [4G11] (GTX10192) biotinylated; Detection: PAPP A antibody [10H9] (GTX10195) labeled with stable Eu3+ -chelate; Antigen: htPAPP-A; Mixture of antibodies and antigen was incubated for 30 minutes at room temperature in streptavidin-coated plates.
Calibration curve for PAPP-A sandwich immunoassay. Capture: PAPP A antibody [4G11] (GTX10192) biotinylated; Detection: PAPP A antibody [10H9] (GTX10195) labeled with stable Eu3+ -chelate; Antigen: htPAPP-A; Mixture of antibodies and antigen was incubated for 30 minutes at room temperature in streptavidin-coated plates.
PAPP A antibody [10H9]
GTX10195
ApplicationsImmunoPrecipitation, ELISA
Product group Antibodies
ReactivityHuman
TargetPAPPA
Overview
- SupplierGeneTex
- Product NamePAPP A antibody [10H9]
- Delivery Days Customer9
- Antibody SpecificityThis antibody is specific to PAPP A subunit of the heterotetrameric complex of PAPP-A (htPAPP-A). It can be used to detect htPAPP-A (when paired with another antibody specific for proMBP) or PAPP-A dimer (when paired with another antibody specific for PAP
- ApplicationsImmunoPrecipitation, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID10H9
- ConjugateUnconjugated
- Gene ID5069
- Target namePAPPA
- Target descriptionpappalysin 1
- Target synonymsASBABP2; aspecific BCL2 ARE-binding protein 2; differentially placenta 1 expressed protein; DIPLA1; IGFBP-4ase; IGF-dependent IGFBP-4 protease; insulin-like growth factor-dependent IGF binding protein-4 protease; PAPA; PAPP-A; PAPPA1; pappalysin-1; pregnancy-associated plasma protein A, pappalysin 1
- HostMouse
- IsotypeIgG2a
- Protein IDQ13219
- Protein NamePappalysin-1
- Scientific DescriptionThis gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203