PARN antibody

GeneTex

PARN antibody

9

Knockdown/Knockout validation was supported by references (PMID:26990993)

WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoPrecipitation, Western Blot

Research Use Only

Polyclonal

1 mg/ml

Unconjugated

Liquid

PARN

poly(A)-specific ribonuclease

DAN; deadenylating nuclease; deadenylation nuclease; DKCB6; PFBMFT4; poly(A)-specific ribonuclease PARN; polyadenylate-specific ribonuclease

Rabbit

IgG

Poly(A)-specific ribonuclease PARN

The protein encoded by this gene is a 3-exoribonuclease, with similarity to the RNase D family of 3-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Human, Mouse

-20°C or -80°C,2°C to 8°C

12352203