PB28 (dihydrochloride)

MedChem Express

PB28 (dihydrochloride) [172907-03-8]

10

172907-03-8

Research Use Only

99.97

C24H40Cl2N2O

443.49

PB28 dihydrochloride, a cyclohexylpiperazine derivative, is a high affinity and selective sigma 2 (sigma2) receptor agonist with a K i of 0.68 nM. PB28 dihydrochloride is also a sigma1 antagonist with a K i of 0.38 nM. PB28 dihydrochloride is less affinity for other receptors. PB28 dihydrochloride inhibits electrically evoked twitch in guinea pig bladder and ileum with EC 50 values of 2.62 microM and 3.96 microM, respectively. PB28 dihydrochloride can modulate SARS-CoV-2-human protein-protein interaction. PB28 dihydrochloride induces caspase-independent apoptosis and has antitumor activity [1] [2] [3] [4] [5] .

[H]Cl.[H]Cl.COC1=CC=CC2=C1CCCC2CCCN3CCN(C4CCCCC4)CC3

2°C to 8°C

12352200