PBX1 Antibody

Cusabio

PBX1 Antibody

20

ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

PBX1

PBX homeobox 1

CAKUHED; homeobox protein PBX1; homeobox protein PRL; pre-B-cell leukemia homeobox 1; pre-B-cell leukemia transcription factor 1

Rabbit

IgG

Pre-B-cell leukemia transcription factor 1

Binds the sequence 5-ATCAATCAA-3. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4. Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B. Together with NKX2-5, it is required for spleen development through a mechanism that involves CDKN2B repression (By similarity).

Human, Rat

-20°C or -80°C

41116161