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PCAF antibody [C3], C-term

Name: PCAF antibody [C3], C-term
SKU: GTX109666_G10
Availability: BackOrder

GTX109666

ApplicationsWestern Blot

Product group Antibodies

TargetKAT2B

Overview

Supplier
GeneTex
Product Name
PCAF antibody [C3], C-term
Delivery Days Customer
9
Application Supplier Note
WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID8850
Target name
KAT2B
Target description
lysine acetyltransferase 2B
Target synonyms
CAF, P/CAF, PCAF, histone acetyltransferase KAT2B, CREBBP-associated factor, K(lysine) acetyltransferase 2B, histone acetylase PCAF, histone acetyltransferase PCAF, p300/CBP-associated factor, spermidine acetyltransferase KAT2B
Host
Rabbit
Isotype
IgG
Protein IDQ92831
Protein Name
Histone acetyltransferase KAT2B
Scientific Description
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Wang SA, Young MJ, Jeng WY, et al. USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy. Sci Rep. 2020,10(1):20870. doi: 10.1038/s41598-020-78000-2
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Sengupta S, Yang C, Hegde ML, et al. Acetylation of oxidized base repair-initiating NEIL1 DNA glycosylase required for chromatin-bound repair complex formation in the human genome increases cellular resistance to oxidative stress. DNA Repair (Amst). 2018,66-67:1-10. doi: 10.1016/j.dnarep.2018.04.001
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Cazzalini O, Sommatis S, Tillhon M, et al. CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis. Nucleic Acids Res. 2014,42(13):8433-48. doi: 10.1093/nar/gku533
Read this paper