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Western blot analysis of extracts of various cell lines using PCDHA12 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using PCDHA12 Polyclonal Antibody at 1:1000 dilution.
Western blot analysis of extracts of various cell lines using PCDHA12 Polyclonal Antibody at 1:1000 dilution.

PCDHA12 Polyclonal Antibody

E-AB-63140
Elabscience
Product group Antibodies
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Overview

  • Supplier
    Elabscience
  • Product Name
    PCDHA12 Polyclonal Antibody
  • Delivery Days Customer
    12
  • Certification
    Research Use Only
  • Scientific Description
    This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
  • UNSPSC
    12352203