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PCSK9 antibody

GTX129859
GeneTex
ApplicationsFlow Cytometry, Western Blot, ELISA
Product group Antibodies
TargetPCSK9
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Overview

  • Supplier
    GeneTex
  • Product Name
    PCSK9 antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry, Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.21 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID255738
  • Target name
    PCSK9
  • Target description
    proprotein convertase subtilisin/kexin type 9
  • Target synonyms
    FH3, FHCL3, HCHOLA3, LDLCQ1, NARC-1, NARC1, PC9, proprotein convertase subtilisin/kexin type 9, convertase subtilisin/kexin type 9 preproprotein, neural apoptosis regulated convertase 1, subtilisin/kexin-like protease PC9
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ8NBP7
  • Protein Name
    Proprotein convertase subtilisin/kexin type 9
  • Scientific Description
    This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3). [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Panighel G, Ferrarese I, Lupo MG, et al. Investigating the in vitro mode of action of okra (Abelmoschus esculentus) as hypocholesterolemic, anti-inflammatory, and antioxidant food. Food Chem (Oxf). 2022,5:100126. doi: 10.1016/j.fochms.2022.100126
    Read this paper
  • Sut S, Tahmasebi A, Ferri N, et al. NMR, LC-MS Characterization of Rydingia michauxii Extracts, Identification of Natural Products Acting as Modulators of LDLR and PCSK9. Molecules. 2022,27(7). doi: 10.3390/molecules27072256
    Read this paper
  • Sut S, Ferrarese I, Lupo MG, et al. The Modulation of PCSK9 and LDLR by Supercritical CO(2) Extracts of Mentha longifolia and Isolated Piperitone Oxide, an In Vitro Study. Molecules. 2021,26(13). doi: 10.3390/molecules26133886
    Read this paper
  • Lupo MG, Marchianò S, Adorni MP, et al. PCSK9 Induces Rat Smooth Muscle Cell Proliferation and Counteracts the Pleiotropic Effects of Simvastatin. Int J Mol Sci. 2021,22(8). doi: 10.3390/ijms22084114
    Read this paper
  • Lammi C, Aiello G, Bollati C, et al. Trans-Epithelial Transport, Metabolism, and Biological Activity Assessment of the Multi-Target Lupin Peptide LILPKHSDAD (P5) and Its Metabolite LPKHSDAD (P5-Met). Nutrients. 2021,13(3). doi: 10.3390/nu13030863
    Read this paper
  • Macchi C, Greco MF, Botta M, et al. Leptin, Resistin, and Proprotein Convertase Subtilisin/Kexin Type 9: The Role of STAT3. Am J Pathol. 2020,190(11):2226-2236. doi: 10.1016/j.ajpath.2020.07.016
    Read this paper
  • Chang HY, Wu JR, Gao WY, et al. The Cholesterol-Modulating Effect of Methanol Extract of Pigeon Pea (Cajanus cajan (L.) Millsp.) Leaves on Regulating LDLR and PCSK9 Expression in HepG2 Cells. Molecules. 2019,24(3). doi: 10.3390/molecules24030493
    Read this paper
  • Gao WY, Chen PY, Chen SF, et al. Pinostrobin Inhibits Proprotein Convertase Subtilisin/Kexin-type 9 (PCSK9) Gene Expression through the Modulation of FoxO3a Protein in HepG2 Cells. J Agric Food Chem. 2018,66(24):6083-6093. doi: 10.1021/acs.jafc.8b02559
    Read this paper
  • Chen SF, Chen PY, Hsu HJ, et al. Xanthohumol Suppresses Mylip/Idol Gene Expression and Modulates LDLR Abundance and Activity in HepG2 Cells. J Agric Food Chem. 2017,65(36):7908-7918. doi: 10.1021/acs.jafc.7b02282
    Read this paper
  • Chen HC, Chen PY, Wu MJ, et al. Tanshinone IIA Modulates Low Density Lipoprotein Uptake via Down-Regulation of PCSK9 Gene Expression in HepG2 Cells. PLoS One. 2016,11(9):e0162414. doi: 10.1371/journal.pone.0162414
    Read this paper

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Figure 1. Western blot analysis of PCSK9 using anti-PCSK9 antibody (A00085-1). Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each lane was loaded with 30 ug of sample under reducing conditions. Lane 1: human A431 whole cell lysates, Lane 2: human Hela whole cell lysates, Lane 3: human CACO-2 whole cell lysates, Lane 4: human HepG2 whole cell lysates, Lane 5: human Jurkat whole cell lysates. After electrophoresis, proteins were transferred to a nitrocellulose membrane at 150 mA for 50-90 minutes. Blocked the membrane with 5% non-fat milk/TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-PCSK9 antigen affinity purified polyclonal antibody (Catalog # A00085-1) at 0.5 microg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:5000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for PCSK9 at approximately 66 kDa, 80 kDa (precursor). The expected band size for PCSK9 is at 72 kDa.
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