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FACS analysis of human PBMCs (PHA stimulation for 3 days) using GTX01495-07 PD-L1 antibody [29E.2A3] (APC). Solid lone : primary antibody Dashed line : isotype control antibody amount : 2 microg (5 microl)
FACS analysis of human PBMCs (PHA stimulation for 3 days) using GTX01495-07 PD-L1 antibody [29E.2A3] (APC). Solid lone : primary antibody Dashed line : isotype control antibody amount : 2 microg (5 microl)
FACS analysis of human PBMCs (PHA stimulation for 3 days) using GTX01495-07 PD-L1 antibody [29E.2A3] (APC). Solid lone : primary antibody Dashed line : isotype control antibody amount : 2 microg (5 microl)

PD-L1 antibody [29E.2A3] (APC)

Research Use Only
GTX01495-07
GeneTex
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman
TargetCD274
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Overview

  • Supplier
    GeneTex
  • Product Name
    PD-L1 antibody [29E.2A3] (APC)
  • Delivery Days Customer
    9
  • Application Supplier Note
    FACS: 2 microg (5 microl) for 105-108 cells in 100 microl sample per test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    Flow Cytometry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    29E.2A3
  • Concentration
    0.4 mg/ml
  • Conjugate
    APC (Allophycocyanin)
  • Formulation
    Liquid
  • Gene ID29126
  • Target name
    CD274
  • Target description
    CD274 molecule
  • Target synonyms
    B7 homolog 1; B7-H; B7H1; CD274 antigen; hPD-L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL1; PD-L1; programmed cell death 1 ligand 1
  • Host
    Mouse
  • Isotype
    IgG2b
  • Protein IDQ9NZQ7
  • Protein Name
    Programmed cell death 1 ligand 1
  • Scientific Description
    This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Lysine demethylase 2A expression in cancer-associated fibroblasts promotes breast tumour growth. Chen JY et al., 2021 Jan, Br J Cancer
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  • TLR9 Mediated Tumor-Stroma Interactions in Human Papilloma Virus (HPV)-Positive Head and Neck Squamous Cell Carcinoma Up-Regulate PD-L1 and PD-L2. Baruah P et al., 2019, Front Immunol
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  • A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells. Barsoum IB et al., 2014 Feb 1, Cancer Res
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  • Allogenicity of human cardiac stem/progenitor cells orchestrated by programmed death ligand 1. Lauden L et al., 2013 Feb 1, Circ Res
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  • Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. Brown JA et al., 2003 Feb 1, J Immunol
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  • PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Latchman Y et al., 2001 Mar, Nat Immunol
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