FACS analysis of human PBMCs (PHA stimulation for 3 days) using GTX01495-07 PD-L1 antibody [29E.2A3] (APC). Solid lone : primary antibody Dashed line : isotype control antibody amount : 2 microg (5 microl)
PD-L1 antibody [29E.2A3] (APC)
GTX01495-07
Overview
- SupplierGeneTex
- Product NamePD-L1 antibody [29E.2A3] (APC)
- Delivery Days Customer9
- Application Supplier NoteFACS: 2 microg (5 microl) for 105-108 cells in 100 microl sample per test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID29E.2A3
- Concentration0.4 mg/ml
- ConjugateAPC (Allophycocyanin)
- FormulationLiquid
- Gene ID29126
- Target nameCD274
- Target descriptionCD274 molecule
- Target synonymsB7 homolog 1; B7-H; B7H1; CD274 antigen; hPD-L1; PDCD1 ligand 1; PDCD1L1; PDCD1LG1; PDL1; PD-L1; programmed cell death 1 ligand 1
- HostMouse
- IsotypeIgG2b
- Protein IDQ9NZQ7
- Protein NameProgrammed cell death 1 ligand 1
- Scientific DescriptionThis gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
- ReactivityHuman
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Lysine demethylase 2A expression in cancer-associated fibroblasts promotes breast tumour growth. Chen JY et al., 2021 Jan, Br J CancerRead more
- TLR9 Mediated Tumor-Stroma Interactions in Human Papilloma Virus (HPV)-Positive Head and Neck Squamous Cell Carcinoma Up-Regulate PD-L1 and PD-L2. Baruah P et al., 2019, Front ImmunolRead more
- A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells. Barsoum IB et al., 2014 Feb 1, Cancer ResRead more
- Allogenicity of human cardiac stem/progenitor cells orchestrated by programmed death ligand 1. Lauden L et al., 2013 Feb 1, Circ ResRead more
- Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. Brown JA et al., 2003 Feb 1, J ImmunolRead more
- PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Latchman Y et al., 2001 Mar, Nat ImmunolRead more