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PD98059

Research Use Only
HY-12028
MedChem Express
CAS Number167869-21-8
DownloadMSDS
Product group Chemicals
Estimated Purity99.96
Molecular Weight267.28
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Overview

  • Supplier
    MedChem Express
  • Product Name
    PD98059 [167869-21-8]
  • Delivery Days Customer
    5
  • CAS Number
    167869-21-8
  • Certification
    Research Use Only
  • Estimated Purity
    99.96
  • Molecular Formula
    C16H13NO3
  • Molecular Weight
    267.28
  • Scientific Description
    PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 microM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 microM) and MEK2 (IC50 of 50 microM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 microM) and AHR transformation (IC50 of 1 microM). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy[1][2][3].
  • SMILES
    O=C1C=C(OC2=CC=CC=C21)C3=CC=CC(OC)=C3N
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352200