Immunohistochemistry of paraffin-embedded Rat retina using PDE6B Polyclonal Antibody at dilution of 1:200 (40x lens).
Immunohistochemistry of paraffin-embedded Rat retina using PDE6B Polyclonal Antibody at dilution of 1:200 (40x lens).
PDE6B Polyclonal Antibody
E-AB-61419
Product group Antibodies
Overview
- SupplierElabscience
- Product NamePDE6B Polyclonal Antibody
- Delivery Days Customer12
- CertificationResearch Use Only
- Scientific DescriptionPhoton absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE), resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell. PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
- UNSPSC12352203