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GTX101468 ICC/IF Image
GTX101468 ICC/IF Image
GTX101468 ICC/IF Image

PDI antibody [N1N3]

Research Use Only
GTX101468
GeneTex
Product group Antibodies
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    PDI antibody [N1N3]
  • Delivery Days Customer
    9
  • Certification
    Research Use Only
  • Concentration
    1 mg/ml
  • Isotype
    IgG
  • Scientific Description
    This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq]
  • Storage Instruction
    2°C to 8°C,-20°C
  • UNSPSC
    12352203

References

  • Downregulation of proteins involved in the endoplasmic reticulum stress response and Nrf2-ARE signaling in lymphoblastoid cells of spinocerebellar ataxia type 17. Lee LC et al., 2014 Jun, J Neural Transm (Vienna)
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  • High glucose-induced proteome alterations in hepatocytes and its possible relevance to diabetic liver disease. Chen JY et al., 2013 Nov, J Nutr Biochem
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  • PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins. Giordano F et al., 2013 Jun 20, Cell
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  • Transcriptional activation of endoplasmic reticulum chaperone GRP78 by HCMV IE1-72 protein. Shi-Chen Ou D et al., 2011 Apr, Cell Res
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