Bio-Connect

PE/AF594 Anti-Mouse CD162 Antibody

Research Use Only
RD30157F
Reddot Biotech
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityMouse
TargetSelplg
Price on request
Packing Size
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    PE/AF594 Anti-Mouse CD162 Antibody
  • Delivery Days Customer
    5
  • Applications
    Flow Cytometry
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    4RA10
  • Concentration
    0.2 mg/ml
  • Conjugate
    Double Conjugated
  • Gene ID20345
  • Target name
    Selplg
  • Target description
    selectin, platelet (p-selectin) ligand
  • Target synonyms
    CD162; Ps; P-selectin glycoprotein ligand 1; Psg; Psgl1; Psgl-1; selectin P ligand; Selp1; Selpl
  • Host
    Rat
  • Isotype
    IgG1
  • Scientific Description
    The 4RA10 antibody reacts with the N-terminal functional peptide of CD162 (P-selectin glycoprotein ligand-1, PSGL-1), encoded by the Selpl gene. PSGL-1 is expressed on the cell surface as a homodimer of approximately 230 kDa. In the mouse, Selpl mRNA is detected in most tissues, with high levels found in hematopoietic cells, brain, and adipose tissue. Flow cytometric analyses have revealed CD162 expression on bone marrow-derived mast and dendritic cells, splenic leukocytes, platelets, peripheral blood neutrophils, and neutrophil and T-cell lines. PSGL-1 is a ligand for P-selectin (CD62P) and is involved in leukocyte rolling, the migration of leukocytes into inflamed tissues, and responses to vascular injury. It is a sialomucin that must be specifically sialylated, fucosylated, and sulfated to bind P-selectin. There is also evidence that other ligands for PSGL-1 and CD62P may exist. 4RA10 mAb is reported to block the binding of mouse leukocytes to CD62P and CD62L.
  • Reactivity
    Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203