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Immunohistochemistry analysis of paraffin-embedded human brain tissue using PECAM-1 (Ab-713) antibody.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using PECAM-1 (Ab-713) antibody.
Immunohistochemistry analysis of paraffin-embedded human brain tissue using PECAM-1 (Ab-713) antibody.

PECAM1 (Ab-713) Antibody

CSB-PA116016
Cusabio
ApplicationsImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse
TargetPECAM1
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Overview

  • Supplier
    Cusabio
  • Product Name
    PECAM1 (Ab-713) Antibody
  • Delivery Days Customer
    20
  • Applications
    ImmunoFluorescence, Western Blot, ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Conjugate
    Unconjugated
  • Gene ID5175
  • Target name
    PECAM1
  • Target description
    platelet and endothelial cell adhesion molecule 1
  • Target synonyms
    CD31; CD31 antigen; CD31/EndoCAM; endoCAM; GPIIA'; PECA1; PECAM-1; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP16284
  • Protein Name
    Platelet endothelial cell adhesion molecule
  • Scientific Description
    Induces susceptibility to atherosclerosis By similarity. Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting detachment signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cells active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC). Tieming Zhao, J. Cell Biol., Jan 2001; 152: 65. SM Watt, Blood, Nov 1993; 82: 2649 - 2663. NETA ILAN, FASEB J, Feb 2001; 15: 362.
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203