PE/Cyanine5.5 Anti-Human CD127/IL-7RA Antibody

Reddot Biotech

PE/Cyanine5.5 Anti-Human CD127/IL-7RA Antibody

5

Flow Cytometry

Research Use Only

Monoclonal

A019D5

Double Conjugated

IL7R

interleukin 7 receptor

CD127; CD127 antigen; CDW127; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL7RA; IL-7R-alpha; ILRA; interleukin 7 receptor alpha chain; interleukin-7 receptor subunit alpha

Mouse

IgG1

CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor Oe+/- chain or IL-7ROe+/-. It forms a heterodimer with the common Oe≥ chain (Oe≥c or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.

Human

2°C to 8°C

12352203