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Chemical Structure
Chemical Structure
Chemical Structure

Pelitinib

SYN-1141
SYNkinase
CAS Number257933-82-7
Product group Chemicals
Estimated Purity>95%
Molecular Weight467.9
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Overview

  • Supplier
    SYNkinase
  • Product Name
    Pelitinib [257933-82-7]
  • Delivery Days Customer
    10
  • CAS Number
    257933-82-7
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Hazard Information
    Warning
  • Molecular Formula
    C24H23ClFN5O2
  • Molecular Weight
    467.9
  • Scientific Description
    Chemical. CAS: 257933-82-7. Formula: C24H23ClFN5O2. MW: 467.9. Pelitinib, also known as EKB 569, is a potent, irreversible inhibitor of the EGFR tyrosine kinase. Cell based IC(50) values range from 39nM to 80nM and in vitro kinase assays are in sub-nanomolar range for EGFR receptors. In xenograft tumor models using overexpressing A431 cells Pelitinib inhibits growth of tumors with effective doses of 3.5-10mg/kg/dl. Recent research also shows that Pelitinib can potentiate radiation induced killing of squamouse cell carcinoma via the inhibition of IR-induced NF-kappaB mediated cell survial pathway. - Pelitinib, also known as EKB 569, is a potent, irreversible inhibitor of the EGFR tyrosine kinase. Cell based IC(50) values range from 39nM to 80nM and in vitro kinase assays are in sub-nanomolar range for EGFR receptors. In xenograft tumor models using overexpressing A431 cells Pelitinib inhibits growth of tumors with effective doses of 3.5-10mg/kg/dl. Recent research also shows that Pelitinib can potentiate radiation induced killing of squamouse cell carcinoma via the inhibition of IR-induced NF-kappaB mediated cell survial pathway.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

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