Pexidartinib (hydrochloride) [2040295-03-0]
HY-16749A
CAS Number2040295-03-0
Product group Chemicals
Estimated Purity99.86
Molecular Weight454.28
Overview
- SupplierMedChem Express
- Product NamePexidartinib (hydrochloride) [2040295-03-0]
- Delivery Days Customer9
- CAS Number2040295-03-0
- CertificationResearch Use Only
- Estimated Purity99.86
- Molecular FormulaC20H16Cl2F3N5
- Molecular Weight454.28
- Scientific DescriptionPexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity[1].
- SMILESFC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F.Cl
- Storage Instruction2°C to 8°C
- UNSPSC12352200