Pexidartinib hydrochloride [2040295-03-0]

TargetMol Chemicals

Pexidartinib hydrochloride [2040295-03-0]

14

2040295-03-0

Chemical

Research Use Only

Pexidartinib hydrochloride

C20H16Cl2F3N5

454.28

Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, selective, orally active, ATP-competitive inhibitor of colony-stimulating factor 1 (CSF1R or M-CSFR) (IC50: 20 nM) and c-Kit (IC50: 10 nM), with 10-100 times greater selectivity for these targets compared to FLT3 (IC50: 160 nM), KDR (VEGFR2) (IC50: 350 nM), and LCK (IC50: 860 nM). Pexidartinib hydrochloride induces apoptosis and exhibits anti-tumor effects.

3 years

Cl.FC(F)(F)c1ccc(CNc2ccc(Cc3c[nH]c4ncc(Cl)cc34)cn2)cn1

-20°C

12352200