PF-04979064

Biorbyt

PF-04979064

16

1220699-06-8

Research Use Only

C24H26N6O3

446.5

PF-04979064 is a highly potent and orally bioavailable PI3K/mTOR dual inhibitor developed through structure-based drug design. It inhibited mTOR, PI3Kalpha, beta, delta and gamma isoforms and AKT phosphorylation with IC50 as 2.64 nM, 0.395 nM, 0.111 nM, 0.122 nM and 28.

C[C@@H](C(N1CCC(N2C(=O)N(C)C3=CN=C4C=CC(C5C=CC(C)=NC=5)=NC4=C23)CC1)=O)O

12352200